What is a liver transplant?

A liver transplant is surgery to replace a diseased liver with a healthy liver from another person. A whole liver may be transplanted, or just part of one. In most cases the healthy liver will come from an organ donor who has just died.

Sometimes a healthy living person will donate part of their liver. A living donor may be a family member. Or it may be someone who is not related to you but whose blood type is a good match. People who donate part of their liver can have healthy lives with the liver that is left.

The liver is the only organ in the body that can replace lost or injured tissue (regenerate). The donor’s liver will soon grow back to normal size after surgery. The part that you receive as a new liver will also grow to normal size in a few weeks.

Who requires a Liver Transplant?

Patients suffering from end-stage renal disease may need a liver transplant. Diseases that may lead to end-stage liver disease are-

• Cirrhosis

• Acute hepatic necrosis

• Biliary atresia

• Viral hepatitis

• Metabolic diseases

• Primary liver cancers

• Autoimmune hepatitis

Types of Liver Transplant

There are two types of liver transplant-

• Living donor liver transplant- As the liver has the capacity to regenerate, a section of the liver is transplanted from a living donor. Both donor and recipient’s liver regenerate within 4 to 8 weeks.

• Deceased donor liver transplant- Liver is transplanted from brain dead or cardiac dead patients.

Who can donate?

• The donor can be a spouse, relative or friend

• The blood group should be compatible

• The donor should be older than 18 years of age.

• The physical and mental health of the donor should be good.

• The donor should have a BMI (Body Mass Index) less than 35

What factors can disqualify a person as a donor?

• HIV infection

• A recent history of cancer

• Any drug addiction

• History of Hepatitis

• Alcoholism

• Psychiatric illness under treatment

• Patients with Heart disease or lung disease

What are the risks of a liver transplant?

Some complications from liver surgery may include:

• Bleeding

• Infection

• Blocked blood vessels to the new liver

• Leakage of bile or blocked bile ducts

• The new liver not working for a short time right after surgery

Your new liver may also be rejected by your body’s disease-fighting system (immune system). Rejection is the body’s normal reaction to a foreign object or tissue. When a new liver is transplanted into your body, your immune system thinks it is a threat and attacks it.

To help the new liver survive in your body, you must take anti-rejection medicines (immunosuppressive medicines). These medicines weaken your immune system’s response. You must take these medicines for the rest of your life.Some liver diseases can come back after transplant.To help the transplant be more successful, you may be started on hepatitis B or C medicines ahead of time, if you have these diseases.

During Transplant

Liver transplant surgery requires a hospital stay. Procedures may vary depending on your condition and your provider’s practices.

Generally, a liver transplant follows this process:

1. You will be asked to remove your clothing and given a gown to wear.

2. An IV (intravenous) line will be started in your arm or hand. Other tubes (catheters) will be put in your neck and wrist. Or they may be put under your collarbone or in the area between your belly and your thigh (the groin).These are used to check your heart and blood pressure, and to get blood samples.

3. You will be placed on your back on the operating table.

4. If there is too much hair at the surgical site, it may be clipped off.

5. A catheter will be put into your bladder to drain urine.

6. After you are sedated, the anesthesiologist will insert a tube into your lungs. This is so that your breathing can be helped with a machine (a ventilator). The anesthesiologist will keep checking your heart rate, blood pressure, breathing, and blood oxygen level during the surgery.

7. The skin over the surgical site will be cleaned with a sterile (antiseptic) solution.

8. The doctor will make a cut (incision) just under the ribs on both sides of your belly. The incision will extend straight up for a short distance over the breast bone.

9. The doctor will carefully separate the diseased liver from the nearby organs and structures.

10. The attached arteries and veins will be clamped to stop blood flow into the diseased liver.

11. Different surgery methods may be used to remove the diseased liver and implant the donor liver. The method used will depend on your specific case.

12. The diseased liver will be removed after it has been cut off from the blood vessels.

13. Your surgeon will check the donor liver before implanting it in your body.

    
    

14. The donor liver will be attached to your blood vessels. Blood flow to your new liver will be started. T he surgeon will check for any bleeding where you have stitches.

15. The new liver will be attached to your bile ducts.

16. The incision will be closed with stitches or surgical staples.

17. A drain may be placed in the incision site to reduce swelling.

18. A sterile bandage or dressing will be applied.

Complications of treatment

After the surgery you may be taken to the recovery room for a few hours before being taken to the intensive care unit (ICU). You will be closely watched in the ICU for several days.

You will be hooked up to monitors. They will show your heartbeat, blood pressure, other pressure readings, breathing rate, and your oxygen level. You will need to stay in the hospital for 1 to 2 weeks or longer.

You will most likely have a tube in your throat. This is so you can breathe with the help of a machine (a ventilator) until you can breathe on your own. You may need the breathing tube for a few hours or a few days, depending on your situation.

You may have a thin plastic tube inserted through your nose into your stomach to remove air that you swallow. The tube will be taken out when your bowels start working normally again. You won’t be able to eat or drink until the tube is removed.

Blood samples will be taken often to check your new liver. They will also check that your kidneys, lungs, and circulatory system are all working.

You may have IV drips to help your blood pressure and your heart, and to control any problems with bleeding. As your condition gets better, these drips will be slowly decreased and turned off. You may receive antibiotics.

Once the breathing and stomach tubes have been removed and you are stable, you may start to drink liquids. You may slowly begin to eat solid foods as directed. Your anti-rejection medicines will be closely watched to be sure you are getting the right dose and the right mix of medicines. When your provider feels you are ready, you will be moved from the ICU to a private room. You will slowly be able to move about more as you get out of bed and walk around for longer periods of time. You will slowly be able to eat more solid foods.

Your transplant team will teach you how to take care of yourself when you go home.

Post discharge at Home

Once you are home, you must keep the surgical area clean and dry. Your provider will give you specific bathing instructions. Any stitches or surgical staples will be removed at a follow-up office visit, if they were not removed before leaving the hospital.

You should not drive until your provider tells you to. You may have other limits on your activity.

Call your healthcare provider if you have any of the following:

• Fever. This may be a sign of rejection or infection.

• Redness, swelling, or bleeding or other drainage from the incision site

• More pain around the incision site. This may be a sign of infection or rejection.

• Vomiting or diarrhea

• Bleeding

• Jaundice (yellowing of the skin and eyes)

What is done to prevent rejection?

You must take medicines for the rest of your life to help the transplanted liver survive in your body. These medicines are called anti-rejection medicines (immunosuppressive medicines). They weaken your immune system’s response.

Each person may react differently to medicines, and each transplant team has preferences for different medicines.

New anti-rejection medicines are always being made and approved. Your provider will create a medicine treatment plan that is right for you. In most cases you will take a few anti-rejection medicines at first. The doses may change often, depending on how you respond to them.

Because anti-rejection medicines affect the immune system, people who have a transplant are at a higher risk for infections. Some of the infections you will be at greater risk for include:

• Oral yeast infection (thrush)

• Herpes

• Respiratory viruses

For the first few months after your surgery, you should avoid contact with crowds or anyone who has an infection.

Each person may have different symptoms of rejection. Some common symptoms of rejection include:

• Fever

• A yellowing of the skin and eyes (jaundice)

• Dark-colored urine

• Itching

• Swollen or sore belly

• Feeling very tired (fatigue)

• Being easily annoyed

• Headache

• Upset stomach

The symptoms of rejection may look like other health problems. Talk with your transplant team about any concerns you have. It is important to see them and speak with them often.